UDP-Glc dehydrogenase (UDPDH)
CBGEN00018
Abbr
UDPDH, Recombinant
Source
E. coli
Species
--
Enzyme Commission Number
1.1.1.22
Molecular Weight
--
Purity
min 95% by SDS-PAGE
Physical Form
Supplied as a lyophilized powder
Package
1U,5U,10U
Description
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate.
Unit Definition
One unit will oxidize 1.0 μmole of UDP-Glc to UDP-GlcA per minute at pH 8.7 and 25 oC.
References
1. UDP-glucose dehydrogenase activity and optimal downstream cellular function require dynamic reorganization at the dimer-dimer subunit interfaces. Hyde AS. et. al. J. Boil. Chem. 288 (49), 35049-35057, 2013. 2. Characterization of two host-specific genes, mannose-sensitive hemagglutinin (mshA) and uridyl phosphate dehydrogenase (UDPDH) that are involved in the Vibrio fscheri-Euprymna tasmanica mutualism. Don Sanjiv Ariyakumar et. al. FEMS Microbiol Lett 299, 65-73, 2009